{"product_id":"protect-5-60ct","title":"Protect+ 5 (60ct)","description":"\u003cp data-start=\"618\" data-end=\"702\"\u003e\u003cstrong data-start=\"621\" data-end=\"702\"\u003eProtect+5 — Comprehensive Fat-Soluble Vitamin and Nutrient Absorption Support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"704\" data-end=\"766\"\u003e\u003cstrong data-start=\"708\" data-end=\"766\"\u003eBalanced Protection for Bone, Heart, and Immune Health\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"30:1-30:105;956-1060\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eFat-soluble vitamins do not work in isolation. Protect+ 5 was formulated around how they work together.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"32:1-32:535;1062-1596\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamins K2, D3, A, and E are each essential for long-term health — but their biological functions are deeply interconnected. Vitamin D3 supports calcium absorption, but without K2 to direct where that calcium goes, absorbed calcium can deposit in the wrong places. Vitamin A supports immune function and cellular renewal, but without Vitamin E protecting its stability, it oxidizes before reaching its targets. Vitamin E protects cell membranes, but optimal activity requires the fat-soluble environment that D3 and A help maintain.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"34:1-34:286;1598-1883\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eProtect+ 5 delivers all four fat-soluble vitamins in their most bioavailable, clinically validated forms — alongside AstraGin® to support absorption — in a single daily formula designed to provide the fat-soluble vitamin foundation that every other longevity intervention builds upon.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"38:1-38:26;1890-1915\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003e\u003cstrong\u003eKEY SUPPORTED BENEFITS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"40:1-40:38;1917-1954\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eProtect+ 5 is formulated to support:*\u003c\/p\u003e\n\u003cul data-sourcepos=\"42:1-49:86;1956-2555\" class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli data-sourcepos=\"42:1-42:109;1956-2064\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eHealthy calcium metabolism — directing calcium to bones and teeth, away from soft tissues and vasculature*\u003c\/li\u003e\n\u003cli data-sourcepos=\"43:1-43:68;2065-2132\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eBone density, skeletal strength, and connective tissue integrity*\u003c\/li\u003e\n\u003cli data-sourcepos=\"44:1-44:67;2133-2199\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eVascular flexibility and healthy arterial calcification defense*\u003c\/li\u003e\n\u003cli data-sourcepos=\"45:1-45:72;2200-2271\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eImmune function, T-cell activity, and balanced inflammatory response*\u003c\/li\u003e\n\u003cli data-sourcepos=\"46:1-46:71;2272-2342\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eCell differentiation, tissue renewal, and mucosal barrier integrity*\u003c\/li\u003e\n\u003cli data-sourcepos=\"47:1-47:55;2343-2397\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eBroad-spectrum lipid-soluble antioxidant protection*\u003c\/li\u003e\n\u003cli data-sourcepos=\"48:1-48:72;2398-2469\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eFat-soluble vitamin absorption and bioavailability through AstraGin®*\u003c\/li\u003e\n\u003cli data-sourcepos=\"49:1-49:86;2470-2555\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eHealthy gene expression associated with calcium homeostasis and cellular longevity*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-sourcepos=\"53:1-53:35;2562-2596\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003e\u003cstrong\u003eTHE FAT-SOLUBLE VITAMIN SYNERGY\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"55:1-55:37;2598-2634\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eWhy K2, D3, A, and E Belong Together\u003c\/p\u003e\n\u003cp data-sourcepos=\"57:1-57:190;2636-2825\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eMost practitioners think of K2 and D3 as a pair — and they are. But Vitamins A and E complete the fat-soluble vitamin system in ways that are clinically important and frequently overlooked.\u003c\/p\u003e\n\u003cp data-sourcepos=\"59:1-59:285;2827-3111\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eD3 activates calcium absorption and supports immune gene expression — but without K2 to activate the osteocalcin and matrix Gla protein (MGP) that direct calcium appropriately, the calcium D3 mobilizes can accumulate in vascular smooth muscle and soft tissue rather than bone matrix.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"61:1-61:329;3113-3441\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eK2 (as MK-7) activates both osteocalcin in bone and MGP in vascular tissue — the two proteins responsible for ensuring calcium flows into bone and away from arteries. This is why the D3-K2 combination addresses both bone health and vascular calcification defense simultaneously, through complementary and sequential mechanisms.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"63:1-63:344;3443-3786\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamin A works alongside D3 through shared nuclear receptor pathways — both vitamins regulate gene expression through the retinoid X receptor (RXR), which forms heterodimers with the vitamin D receptor (VDR) for D3 and the retinoic acid receptor (RAR) for Vitamin A. Both vitamins are therefore needed for optimal downstream gene expression.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"65:1-65:220;3788-4007\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamin E stabilizes the other fat-soluble vitamins — protecting Vitamins A and D3 from oxidative degradation in the lipid environment of cell membranes and lipoproteins, extending their effective circulating activity.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"67:1-67:140;4009-4148\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eProtect+ 5 delivers all four in a single formula — because fat-soluble vitamin nutrition is a system, not a set of individual supplements.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"71:1-71:15;4155-4169\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003e\u003cstrong\u003eTHE FORMULA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"75:1-75:66;4176-4241\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cstrong\u003eK2VITAL® Delta (Vitamin K2 as MK-7, Double Microencapsulated)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"76:1-78:91;4242-4424\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eDose: 300 mcg Role: Calcium Direction, Bone Matrix Support \u0026amp; Vascular Calcification Defense by Balchem (formerly Kappa Bioscience) · World's Only Patented Double-Microencapsulated K2\u003c\/p\u003e\n\u003cp data-sourcepos=\"80:1-80:246;4426-4671\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamin K2 as MK-7 is the most biologically active and longest-lasting form of supplemental vitamin K2 — with a 72-hour half-life compared to K1's 2–4 hours, and far superior tissue distribution and bone\/vascular activity compared to K2 as MK-4.\u003c\/p\u003e\n\u003cp data-sourcepos=\"82:1-82:189;4673-4861\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eK2VITAL® Delta is the most advanced K2 MK-7 ingredient available — the world's first and only patented double-microencapsulated vitamin K2 preparation. This distinction matters clinically:\u003c\/p\u003e\n\u003cp data-sourcepos=\"84:1-84:460;4863-5322\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eThe stability problem with conventional K2: Vitamin K2 MK-7 is naturally sensitive to degradation — particularly in the presence of minerals (calcium, magnesium), alkaline environments, and manufacturing pressure. Independent testing across hundreds of commercially available K2 products found that most contain significantly less K2 than their labels claim by the time they reach the consumer, due to degradation during manufacturing, blending, and storage.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"86:1-86:297;5324-5620\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eK2VITAL® Delta's double-coated microencapsulation technology protects MK-7 from mineral degradation, with stability superiority confirmed across over 400 tests of finished products — achieving MK-7 recovery rates above 95% in calcium and mineral formulations where conventional K2 would degrade.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"88:1-88:263;5622-5884\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eK2VITAL® Delta maintains a minimum 99.7% all-trans isomer purity — the fully bioactive form identical to the K2 molecule found in nature. The cis-isomers found in lower-quality K2 ingredients are not biologically active and do not activate K-dependent proteins.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"90:1-90:36;5886-5921\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eClinical Evidence — K2VITAL® MK-7:*\u003c\/p\u003e\n\u003cul data-sourcepos=\"91:1-94:106;5922-6748\" class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli data-sourcepos=\"91:1-91:344;5922-6265\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eA 2024 peer-reviewed study published in the Journal of the American College of Cardiology demonstrated that Vitamin K2 MK-7 combined with Vitamin D3 significantly impeded the progression of coronary artery calcification (CAC) — directly validating the vascular calcification defense mechanism at the heart of Protect+ 5's D3+K2 combination.*\u003c\/li\u003e\n\u003cli data-sourcepos=\"92:1-92:204;6266-6469\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eMenaQ7 Proof of Concept study (Knapen et al., Thrombosis and Haemostasis, 2015): 180 mcg MK-7 daily for 3 years significantly improved arterial stiffness in healthy postmenopausal women versus placebo*\u003c\/li\u003e\n\u003cli data-sourcepos=\"93:1-93:173;6470-6642\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eMultiple clinical trials confirm MK-7 supplementation increases osteocalcin carboxylation, supporting bone matrix mineralization and healthy bone density in aging adults*\u003c\/li\u003e\n\u003cli data-sourcepos=\"94:1-94:106;6643-6748\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eK2VITAL® has been used as the reference standard in the AVADEC, RENAKVIT, and TAKEOVER clinical trials*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-sourcepos=\"96:1-96:24;6750-6773\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eBiological mechanisms:*\u003c\/p\u003e\n\u003cul data-sourcepos=\"97:1-99:121;6774-7154\" class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli data-sourcepos=\"97:1-97:113;6774-6886\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eActivates osteocalcin — the protein that binds calcium into bone matrix, supporting bone density and strength*\u003c\/li\u003e\n\u003cli data-sourcepos=\"98:1-98:147;6887-7033\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eActivates Matrix Gla Protein (MGP) — the most potent known inhibitor of vascular calcification, preventing calcium deposition in arterial walls*\u003c\/li\u003e\n\u003cli data-sourcepos=\"99:1-99:121;7034-7154\" class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports healthy carboxylation of all vitamin K-dependent proteins across bone, vasculature, kidney, and brain tissue*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-sourcepos=\"101:1-101:185;7156-7340\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eAt 300 mcg, Protect+ 5 delivers K2VITAL® Delta at the upper end of the clinically studied supplemental range — providing meaningful MK-7 activity across both bone and vascular tissue.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"101:1-101:185;7156-7340\" class=\"font-claude-response-body break-words whitespace-normal\"\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0655\/5287\/5766\/files\/hydrovita-k2_480x480.jpg?v=1661869348\" alt=\"\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0655\/5287\/5766\/files\/Screen_Shot_2022-09-22_at_8.59.46_AM_480x480.png?v=1663851623\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"105:1-105:33;7347-7379\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cstrong\u003eVitamin D3 (Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"106:1-107:70;7380-7474\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eDose: 125 mcg (5,000 IU) Role: Calcium Absorption, Immune Gene Expression \u0026amp; Cellular Signaling\u003c\/p\u003e\n\u003cp data-sourcepos=\"109:1-109:249;7476-7724\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamin D3 is the most physiologically active form of supplemental vitamin D — the form produced endogenously in the skin upon UV exposure and the form that undergoes activation to 25(OH)D3 in the liver and 1,25(OH)2D3 (calcitriol) in the kidneys.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"111:1-111:292;7726-8017\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eAt 5,000 IU, Protect+ 5 delivers D3 at a clinically meaningful dose for individuals with suboptimal vitamin D status — which includes the majority of adults in northern latitudes, those with limited sun exposure, darker skin tones, obesity, or age-related declining D3 synthesis efficiency.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"127:1-127:24;9343-9366\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cstrong\u003eVitamin A (Retinol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"128:1-129:74;9367-9474\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eDose: Clinically appropriate dose Role: Cell Differentiation, Mucosal Immunity, Tissue Renewal \u0026amp; D3 Synergy\u003c\/p\u003e\n\u003cp data-sourcepos=\"131:1-131:138;9476-9613\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamin A (as retinol) is essential for a wide range of biological processes that are directly relevant to longevity and clinical health:\u003c\/p\u003e\n\u003cp data-sourcepos=\"133:1-133:291;9615-9905\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eCell differentiation and tissue renewal: Vitamin A regulates the differentiation of stem cells into specialized cell types across skin, respiratory epithelium, intestinal epithelium, and immune tissue — supporting the ongoing tissue renewal processes that maintain organ function with age.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"145:1-145:35;11091-11125\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cstrong\u003eVitamin E (d-alpha Tocopherol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"146:1-147:96;11126-11255\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eDose: Clinically appropriate dose Role: Lipid-Soluble Antioxidant Defense, Membrane Integrity \u0026amp; Fat-Soluble Vitamin Stabilization\u003c\/p\u003e\n\u003cp data-sourcepos=\"149:1-149:246;11257-11502\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eVitamin E is the body's primary lipid-soluble chain-breaking antioxidant — integrated directly into cell membranes and lipoproteins where it interrupts lipid peroxidation chain reactions before they propagate through the membrane lipid bilayer.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"151:1-151:299;11504-11802\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eUnlike water-soluble antioxidants (vitamin C, glutathione) that protect the aqueous cellular compartments, Vitamin E specifically protects the lipid-rich environments that are the site of greatest oxidative vulnerability — cell membranes, mitochondrial membranes, myelin sheaths, and lipoproteins.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"165:1-165:74;12866-12939\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cstrong\u003eAstraGin® (Astragalus membranaceus + Panax notoginseng Root Extracts)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-sourcepos=\"166:1-168:17;12940-13036\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eDose: 50 mg Role: Fat-Soluble Vitamin Absorption \u0026amp; Bioavailability Optimization \u003c\/p\u003e\n\u003cp data-sourcepos=\"170:1-170:148;13038-13185\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eAstraGin® upregulates key intestinal nutrient transporter proteins — supporting the absorption of fat-soluble vitamins across the intestinal wall.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"172:1-172:406;13187-13592\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eFat-soluble vitamins are absorbed through a lipid-dependent process involving bile acid micelles, pancreatic lipases, and specific intestinal transport proteins. AstraGin® supports the expression of these transport systems — including those involved in fat-soluble nutrient uptake — ensuring that the clinically validated forms of K2, D3, A, and E in Protect+ 5 are absorbed efficiently and consistently.*\u003c\/p\u003e\n\u003cp data-sourcepos=\"174:1-174:233;13594-13826\" class=\"font-claude-response-body break-words whitespace-normal\"\u003eAstraGin® also supports gut barrier integrity and healthy inflammatory tone in the intestinal environment — contributing to the absorptive surface health that determines fat-soluble vitamin bioavailability at the fundamental level.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eVitamin K2 MK-7:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eLal N, Berenjian A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Appl Microbiol Biotechnol. 2020 Apr;104(7):2765-2776. doi: 10.1007\/s00253-020-10409-1. Epub 2020 Feb 3. PMID: 32009201.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSato T, Inaba N, Yamashita T. MK-7 and Its Effects on Bone Quality and Strength. Nutrients. 2020 Mar 31;12(4):965. doi: 10.3390\/nu12040965. PMID: 32244313; PMCID: PMC7230802.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eKnapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160\/TH14-08-0675. Epub 2015 Feb 19. PMID: 25694037.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSimes DC, Viegas CSB, Araújo N, Marreiros C. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci. 2019 Aug 25;20(17):4150. doi: 10.3390\/ijms20174150. PMID: 31450694; PMCID: PMC6747195.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePisoschi AM, Pop A, Iordache F, Stanca L, Geicu OI, Bilteanu L, Serban AI. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy. Eur J Med Chem. 2022 Mar 15;232:114175. doi: 10.1016\/j.ejmech.2022.114175. Epub 2022 Feb 4. PMID: 35151223; PMCID: PMC8813210.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eVitamin D: \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eChang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019 Jun;60(3):237-244. doi: 10.1016\/j.pedneo.2019.04.007. Epub 2019 Apr 17. PMID: 31101452.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMartens PJ, Gysemans C, Verstuyf A, Mathieu AC. Vitamin D's Effect on Immune Function. Nutrients. 2020 Apr 28;12(5):1248. doi: 10.3390\/nu12051248. PMID: 32353972; PMCID: PMC7281985.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAo T, Kikuta J, Ishii M. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021 Nov 3;11(11):1624. doi: 10.3390\/biom11111624. PMID: 34827621; PMCID: PMC8615708.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAbiri B, Vafa M. Vitamin D and Muscle Sarcopenia in Aging. Methods Mol Biol. 2020;2138:29-47. doi: 10.1007\/978-1-0716-0471-7_2. PMID: 32219739.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eVitamin A:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eBar-El Dadon S, Reifen R. Vitamin A and the epigenome. Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2404-2411. doi: 10.1080\/10408398.2015.1060940. PMID: 26565606.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eConaway HH, Henning P, Lerner UH. Vitamin a metabolism, action, and role in skeletal homeostasis. Endocr Rev. 2013 Dec;34(6):766-97. doi: 10.1210\/er.2012-1071. Epub 2013 May 29. PMID: 23720297.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStephensen CB, Lietz G. Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2. Br J Nutr. 2021 Dec 14;126(11):1663-1672. doi: 10.1017\/S0007114521000246. Epub 2021 Jan 20. PMID: 33468263; PMCID: PMC7884725.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol. 2019 Apr;54(2):184-192. doi: 10.1080\/10409238.2019.1611734. Epub 2019 May 14. PMID: 31084433; PMCID: PMC6629036.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eVitamin E: \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ePekmezci D. Vitamin E and immunity. Vitam Horm. 2011;86:179-215. doi: 10.1016\/B978-0-12-386960-9.00008-3. PMID: 21419272.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCasati M, Boccardi V, Ferri E, Bertagnoli L, Bastiani P, Ciccone S, Mansi M, Scamosci M, Rossi PD, Mecocci P, Arosio B. Vitamin E and Alzheimer's disease: the mediating role of cellular aging. Aging Clin Exp Res. 2020 Mar;32(3):459-464. doi: 10.1007\/s40520-019-01209-3. Epub 2019 May 3. PMID: 31054115.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCorina A, Rangel-Zúñiga OA, Jiménez-Lucena R, Alcalá-Díaz JF, Quintana-Navarro G, Yubero-Serrano EM, López-Moreno J, Delgado-Lista J, Tinahones F, Ordovás JM, López-Miranda J, Pérez-Martínez P. Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study. J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):770-777. doi: 10.1093\/gerona\/gly195. PMID: 30165472.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMoriguchi S, Muraga M. Vitamin E and immunity. Vitam Horm. 2000;59:305-36. doi: 10.1016\/s0083-6729(00)59011-6. PMID: 10714244.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eAstraGin®\u003c\/span\u003e\u003cspan\u003e:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eChang, Tsu-Chung et al. “Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+\/glucose cotransporter 1 expression.” \u003c\/span\u003e\u003ci\u003e\u003cspan\u003eJournal of agricultural and food chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan\u003e vol. 55,5 (2007): 1993-8. doi:10.1021\/jf062714k\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eDuring A, Harrison EH. Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res. 2007 Oct;48(10):2283-94. doi: 10.1194\/jlr.M700263-JLR200. Epub 2007 Jul 20. PMID: 17644776.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eReboul E, Goncalves A, Comera C, Bott R, Nowicki M, Landrier JF, Jourdheuil-Rahmani D, Dufour C, Collet X, Borel P. Vitamin D intestinal absorption is not a simple passive diffusion: evidence for involvement of cholesterol transporters. Mol Nutr Food Res. 2011 May;55(5):691-702. doi: \u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eReboul E. Vitamin E intestinal absorption: Regulation of membrane transport across the enterocyte. IUBMB Life. 2019 Apr;71(4):416-423. doi: 10.1002\/iub.1955. Epub 2018 Oct 11. PMID: 30308094.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCaution:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cspan\u003eIndividuals taking more than 50 mcg (2,000 IU) of Vitamin D per day should have their vitamin D levels monitored. This product is not intended for long term use and should be used under the supervision of your doctor. \u003c\/span\u003e\u003c\/p\u003e","brand":"Healthgevity","offers":[{"title":"Default Title","offer_id":45955618471970,"sku":null,"price":45.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0798\/6223\/5170\/files\/Protect_5bottle.webp?v=1783623359","url":"https:\/\/palominoifmshop.myshopify.com\/products\/protect-5-60ct","provider":"palominoifmshop","version":"1.0","type":"link"}